Epithelial–Mesenchymal Transition in a Case of Metastatic Thyroid Carcinoma in a Brown Bear (Ursus arctos)

A 20-year-old male brown bear (Ursus arctos) with a 20 × 25 cm necrotic mass adjacent to the trachea was diagnosed as having an anaplastic thyroid carcinoma. Metastases were observed in the lungs and one adrenal gland and, histologically, these had anaplastic and follicular carcinoma patterns, respectively. E-cadherin labelling was observed in the adrenal mass only, while N-cadherin immunolabelling was detected in the thyroid gland and lung masses. Thyroid-specific markers (thyroid transcription factor-1, thyroglobulin) were expressed in the adrenal gland metastasis. This case illustrates an example of a primary epithelial–mesenchymal transition (EMT) enabling metastasis to distant organ sites, followed by a mesenchymal–epithelial transition within the adrenal gland microenvironment, allowing invasion and reacquisition of thyroid epithelial cell features. EMTs help to understand the phenomenon of carcinoma cell plasticity in enabling colonization and growth of metastases

COVID-19: impactos na saúde mental e psicossociais na América Latina

The COVID-19 pandemic has not only had health, economic, and political impacts, but also significant psychosocial and mental health consequences worldwide. In this article, different documentation and studies on mental health were analyzed, with the aim of identifying the various problems detected during the pandemic. Methodologically, a narrative and integrative review of the scientific literature was carried out. In Latin America, the most recent studies have documented and made patent effects on the various vulnerized populations such as migrants, women, children, the elderly, people living with significant disabilities, people experiencing marked housing and food insecurity, and temporary workers laboring in what has been referred to as the informal economy. In light of this, it is proposed that addressing these issues should involve the coordination of transnational policies and the definition of an agenda of critical priorities to focus and address. For this to come about, it is important that the empirical evidence generated by regional epidemiological studies contribute to the design of public policies on mental health of the Latin American population, so that they reduce the negative effects as well as prevent the future consequences of a pandemic that is not yet over.La pandemia por el COVID-19 no sólo ha generado diversos impactos en materia de salud, economía y política, sino también importantes consecuencias psicosociales y de salud mental en el mundo. En este trabajo, se analizaron diferentes documentaciones y estudios sobre salud mental, con el objetivo de recuperar las diversas problemáticas detectadas durante la pandemia. Metodológicamente se realizó una revisión narrativa e integrativa de la literatura científica. En América Latina los estudios más recientes comienzan a visualizar diferentes afectaciones sobre las diversas poblaciones vulneralizadas: migrantes, mujeres, niños, los ancianos, personas quienes viven con una discapacidad significativa, personas en situación de calle, trabajadores informales, etc. Frente a este panorama, se plantea que el abordaje de estas cuestiones deberá contar con la coordinación de políticas trasnacionales y la definición de una agenda de prioridades críticas a focalizar y atender. Para esto resulta importante que la evidencia empírica generada por los estudios epidemiológicos regionales contribuya al diseño de las políticas públicas sobre salud mental de la población latinoamericana, de modo que las mismas logren reducir los efectos negativos como también puedan prevenir las consecuencias futuras de una pandemia que todavía no ha finalizado.A pandemia da COVID-19 no mundo tem impactado a área da saúde, os setores da economia e da política e também tem gerado consequências psicossociais, repercutindo de forma significativa no campo da saúde mental. Este estudo de revisão sistemática analisou diversos documentos e pesquisas abordando saúde mental e COVID-19, bem como problematicas geradas durante a pandemia. A metodologia de pesquisa envolveu revisão narrativa e integrativa da literatura científica. Na América Latina, os estudos mais recentes apresentam os inúmeros efeitos da COVID-19 em populações vulneráveis: imigrantes, mulheres, crianças, idosos, pessoas em situação de rua, trabalhadores informais, etc. Diante desse panorama, propõe-se que a abordagem dessas questões inclua a coordenação de políticas transnacionais e a definição de uma agenda de prioridades críticas a serem consideradas. Os resultados empíricos de estudos epidemiológicos realizados em âmbito regional contribuíram para o desenho de políticas públicas em saúde mental da população latino-americana com o objetivo de reduzir os efeitos negativos e prevenir riscos futuros de uma pandemia que ainda não terminou.Fil: Gallegos de San Vicente, Miguel Omar. Pontifícia Universidade Católica de Minas Gerais; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto Rosario de Investigaciones en Ciencias de la Educación. Universidad Nacional de Rosario. Instituto Rosario de Investigaciones en Ciencias de la Educación; ArgentinaFil: Consoli, Andrés J.. University of California; Estados UnidosFil: Ferrari, Ilka Franco. Pontifícia Universidade Católica de Minas Gerais; BrasilFil: Cervigni, Mauricio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto Rosario de Investigaciones en Ciencias de la Educación. Universidad Nacional de Rosario. Instituto Rosario de Investigaciones en Ciencias de la Educación; ArgentinaFil: de Castro Peçanha, Viviane. The Chicago School of Professional Psychology; Estados UnidosFil: Martino, Pablo Luis. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Caycho Rodríguez, Tomás. Universidad Privada del Norte; PerúFil: Razumovskiy, Anastasia. No especifíca

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

The R2TP/Prefoldin-like co-chaperone, in concert with HSP90, facilitates assembly and cellular stability of RNA polymerase II, and complexes of PI3-kinase-like kinases such as mTOR. However, the mechanism by which this occurs is poorly understood. Here we use cryo-EM and biochemical studies on the human R2TP core (RUVBL1–RUVBL2–RPAP3–PIH1D1) which reveal the distinctive role of RPAP3, distinguishing metazoan R2TP from the smaller yeast equivalent. RPAP3 spans both faces of a single RUVBL ring, providing an extended scaffold that recruits clients and provides a flexible tether for HSP90. A 3.6 Å cryo-EM structure reveals direct interaction of a C-terminal domain of RPAP3 and the ATPase domain of RUVBL2, necessary for human R2TP assembly but absent from yeast. The mobile TPR domains of RPAP3 map to the opposite face of the ring, associating with PIH1D1, which mediates client protein recruitment. Thus, RPAP3 provides a flexible platform for bringing HSP90 into proximity with diverse client proteins

X-ray Orbital Modulations in Intermediate Polars

We present an analysis of 30 archival ASCA and RXTE X-ray observations of 16 intermediate polars to investigate the nature of their orbital modulation. We show that X-ray orbital modulation is widespread amongst these systems, but not ubiquitous as indicated by previous studies that included fewer objects. Only seven of the sixteen systems show a clearly statistically significant modulation depth whose amplitude decreases with increasing X-ray energy. Interpreting this as due to photoelectric absorption in material at the edge of an accretion disc would imply that such modulations are visible for all system inclination angles in excess of 60 degrees. However, it is also apparent that the presence of an X-ray orbital modulation can appear and disappear on a timescale of ~years or months in an individual system. This may be evidence for the presence of a precessing, tilted accretion disc, as inferred in some low mass X-ray binaries.Comment: Accepted for publication in Astronomy & Astrophysics. 9 pages of text, plus 5 pages of tables, plus 33 pages of figure

1RXSJ062518.2+733433: A new intermediate polar

We report the identification of the cataclysmic variable 1RXSJ062518.2+733433 as an intermediate polar. The orbital period of the system is determined to be 283.0+-2 min from the radial velocity variation of Halpha, measured in an extensive set of time-resolved spectroscopy. Differential optical photometry obtained over a base line of three weeks reveals the presence of coherent variability with a period of 19.788+-0.002 min, which we suggest to be the white dwarf spin period. The power spectrum of our photometry also contains a strong signal near the spectroscopically determined orbital period. The emission lines in 1RXSJ062518.2+733433 display a complex multicomponent structure. In the trailed spectrogram of HeI 6678 we detect a narrow component with a radial velocity semi-amplitude of ~140kms, consistent with a possible origin on the irradiated face of the secondary. The absence of eclipses gives an upper limit on the binary inclination of i<=60deg.Comment: 7 pages, A&A-Latex, 9 Figures, accepted for publication in A&

Limits to the muon flux from WIMP annihilation in the center of the Earth with the AMANDA detector

A search for nearly vertical up-going muon-neutrinos from neutralino annihilations in the center of the Earth has been performed with the AMANDA-B10 neutrino detector. The data sample collected in 130.1 days of live-time in 1997, ~10^9 events, has been analyzed for this search. No excess over the expected atmospheric neutrino background is oberved. An upper limit at 90% confidence level on the annihilation rate of neutralinos in the center of the Earth is obtained as a function of the neutralino mass in the range 100 GeV-5000 GeV, as well as the corresponding muon flux limit.Comment: 14 pages, 11 figures. Version accepted for publication in Physical Review

Results from the Antarctic Muon and Neutrino Detector Array (AMANDA)

We show new results from both the older and newer incarnations of AMANDA (AMANDA-B10 and AMANDA-II, respectively). These results demonstrate that AMANDA is a functioning, multipurpose detector with significant physics and astrophysics reach. They include a new higher-statistics measurement of the atmospheric muon neutrino flux and preliminary results from searches for a variety of sources of ultrahigh energy neutrinos: generic point sources, gamma-ray bursters and diffuse sources producing muons in the detector, and diffuse sources producing electromagnetic or hadronic showers in or near the detector.Comment: Invited talk at the XXth International Conference on Neutrino Physics and Astrophysics (Neutrino 2002), Munich, Germany, May 25-30, 200

The Pierre Auger Observatory III: Other Astrophysical Observations

Astrophysical observations of ultra-high-energy cosmic rays with the Pierre Auger ObservatoryComment: Contributions to the 32nd International Cosmic Ray Conference, Beijing, China, August 201

Operations of and Future Plans for the Pierre Auger Observatory

Technical reports on operations and features of the Pierre Auger Observatory, including ongoing and planned enhancements and the status of the future northern hemisphere portion of the Observatory. Contributions to the 31st International Cosmic Ray Conference, Lodz, Poland, July 2009.Comment: Contributions to the 31st ICRC, Lodz, Poland, July 200